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After oral administration ciprofloxacin is quickly absorbed mainly in the small intestine. The maximum ciprofloxacin concentrations in serum is reached after 1.2 hours. The bioavailability is about 70-80%. The values of the maximum plasma concentration buy sustanon 250 and area under the curve “concentration – time» increases proportionally with dose. DistributionCommunication ciprofloxacin to plasma proteins is 20-30%; the active substance is present in the plasma mainly in the non-ionized form.  Is freely distributed in tissues and body fluids. The volume of distribution in the body is about 2-3 l / kg. Ciprofloxacin concentration in tissues is significantly higher than in serum concentration. Metabolism Biotransformiroetsa liver.

The blood can be detected four metabolite ciprofloxacin in small concentrations: dietiltsiprofloksatsin  sulfotsiprofloksatsin , oksotsiprofloksatsin buy sustanon 250, formiltsiprofloksatsin  exhibit antibacterial activity in vitro, comparable to the antibacterial activity of nalidixic acid. The antibacterial activity in vitro metabolite M4 present in smaller quantities more in line with the activity of norfloxacin.Excretion Ciprofloxacin is excreted from the body mainly by the kidneys by glomerular filtration and tubular secretion; small quantity – through the gastrointestinal tract. Renal clearance of 0.18-0.3 l / h / kg, total clearance – 0,48-0,60 l / h / kg. Approximately 1% of the administered dose is excreted in the bile. The bile ciprofloxacin is present in high concentrations. In patients with intact renal function the half-life is usually 3-5 hours. In case of violation of renal function  is increased.

 

Indications
Uncomplicated and complicated infections caused  microorganisms. Adults

  • respiratory tract infection. Refer a buy sustanon 250 appoint nevmoniyah caused by Klebsiella spp., Enterobacter spp., Proteus spp., Esherichia coli, Pseudomonas aeruginosa, Haemophilus spp., Moraxella catarrhalis, Legionella spp. , And staphylococci,
  • middle ear infections (otitis media), sinuses (sinusitis), especially if these infections are caused by gram-negative organisms, including Pseudomonas aeruginosa or Staphylococcus,
  • Eye infections
  • renal infections and / or urinary tract.
  • genital infections, including adnexitis, gonorrhea, prostatitis,
  • abdominal infections (bacterial infections of the gastrointestinal tract, biliary tract, peritonitis)
  • Skin and soft tissue infections,
  • sepsis,
  • infection, or the prevention of infections in patients with reduced immunity (patients taking immunosuppressive drugs, or patients with neutropenia)
  • Selective intestinal decontamination in patients with reduced immunity,
  • prevention and buy sustanon testosterone 250 treatment of inhalational anthrax (infection of Bacillus anthracis ),
  • prevention of invasive infections caused by Neisseria meningitidis .

It is necessary to take into account the current official guidance on the rules of use of antibacterial agents.