Simultaneous administration of and corticosteroids may increase the risk of tendon rupture.
Simultaneous nazanachenie ciprofloxacin sust steroids and phenytoin can result in an increase or decrease in serum concentration of phenytoin.
Metoclopramide accelerates the absorption of ciprofloxacin, which reduces the time to reach its maximum concentration in plasma. Co-administration of uricosuric drugs leads to excretion slow down (to 50%) and increase in the plasma concentration of ciprofloxacin. When combined with other antimicrobial agents (beta-lactams, aminoglycosides, clindamycin, metronidazole) commonly observed synergism: the drug can be successfully applied in combination with ceftazidime and azlocillin in infections caused by Pseudomonas spp .; with mezlocillin, azlocillin and other beta-lactam antibiotics – in streptococcal infections; with izoksazolilpenitsillinami and vancomycin – with staphylococcal infections; metronidazole and clindamycin – In anaerobic infections.
If you encounter during or after the sust steroids treatment with ciprofloxacin severe and prolonged diarrhea should exclude the diagnosis of pseudomembranous colitis, which requires immediate discontinuation of the drug and appropriate treatment. In the event or pains in the tendons at the first signs tenosynovitis treatment should cease due to the fact that separate cases (mainly in elderly patients concomitantly receiving glucocorticoids) and inflammation of tendons even rupture during treatment fluoroquinolones. During therapy with ciprofloxacin are advised to avoid excessive physical exertion.
During treatment with ciprofloxacin, in order to avoid the development of crystalluria is unacceptable excess of the recommended daily dose. Also, you must acquire a sufficient amount of fluid (under the control of diuresis) to comply with normal urine output and maintain acidic urine. During treatment with ciprofloxacin should avoid UV exposure (including exposure to direct sunlight).
During therapy may increase the prothrombin index (during surgery should monitor the status of the blood coagulation system).
Patients with deficiency of glucose-6-dehydrogenase appointment tsiprinol can cause the development of hemolytic anemia. During treatment, patients should sust steroids not drink alcohol.
Effects on ability to management of motor transport and other mechanisms
Patients taking ciprofloxacin should be careful when driving and busy with other potentially hazardous activities that require increased attention and psychomotor speed reactions (especially with simultaneous use of alcohol).
tablets, film-coated, 250 mg and 500 mg.
10 tablets in blister. 1 blister in a cardboard box sust steroids with instructions for use.