Marked atherosclerosis cerebrovascular, renal and / or hepatic impairment, advanced age, lack of glucose-6-dehydrogenase (the risk of hemolytic anemia), glucocorticosteroid therapy.
Dosing and Administration
Inside, 1 time per day. The drug should be taken sustanol after meals, the tablet be swallowed whole without chewing and drinking plenty of fluids. Ciprofloxacin dose depends on the severity of the disease, the type of infection, the body status, age, weight and kidney function in the patient.
Side effects From the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with a history of liver disease), hepatitis, gepatonekroz, pseudomembranous colitis.
On the part of the central and peripheral nervous system: dizziness, headache, fatigue, agitation, convulsions, anxiety, tremor, insomnia, “nightmarish” dream, peripheral paralgeziya (anomaly perception of feeling pain), hypersensitivity, gipostezii, sweating, increased intracranial pressure, confusion, depression, hallucinations, and other symptoms of psychotic reactions (sometimes progressing to states in which the patient may self-harm, suicidal tendencies), migraine.
From the senses: the taste and smell, taste loss sustanol (transient), blurred vision (diplopia, changes in color vision), tinnitus, hearing loss, transient hearing loss (particularly high frequencies).
Cardio vascular system: tachycardia, cardiac arrhythmias, lowering blood pressure (BP), fainting, feeling of “tides” of blood to the skin of the face, thrombosis of cerebral arteries, peripheral edema.
From the hematopoietic system: leukopenia, granulocytopenia, anemia, grombotsitopeniya, leukocytosis, thrombocytosis, haemolytic anemia, pancytopenia, agranulocytosis, inhibition of bone marrow hematopoiesis.
From the urinary system: hematuria, crystalluria (particularly in alkaline urine and low urine output), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, decreased azotovydelitelnoy renal function, interstitial nephritis.
Allergic reactions: itching, rash, blisters, accompanied by bleeding and small nodules, forming scabs, drug fever, petechial hemorrhages (petechiae), swelling of the face or throat, shortness of breath, eosinophilia, vasculitis, rash, nodular erythema, exudative erythema multiforme, syndrome Stevens-Johnson (malignant exudative erythema), toxic epidermal necrolysis (Lyell’s syndrome), anaphylactic shock, serum sickness.
From the Musculoskeletal System: arthralgia, arthritis, tenosynovitis, tendon ruptures, myalgia, swelling in the joint.
Other: general weakness, superinfection (candidiasis, pseudomembranous colitis), increased sensitivity to light
From the laboratory parameters: hypoprothrombinemia, increased activity of “liver” transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperuricemia, hyperglycemia.
Overdosing Symptoms: nausea, vomiting, diarrhea, headache and dizziness, disorders of the liver and kidneys, crystalluria and haematuria, in more severe cases, confusion, tremors, hallucinations, and seizures.
Treatment: symptomatic, gastric lavage, the sustanol appointment of activated charcoal and laxatives; ensure adequate intake of fluid. A specific antidote is not known. Haemodialysis does not have the clinical effect of intoxication.