testosterone sustanon
testosterone sustanon

Antimicrobial wide spectrum of action of the fluoroquinolones. Effective bactericidal. The drug inhibits  gyrase enzyme bacteria, thereby violated replication and protein synthesis of bacteria cell. Low toxicity to host cells is explained by the absence of testosterone sustanon gyrase. While receiving ciprofloxacin occurs parallel to others making stability. Antibiotics, not belonging to the group of gyrase inhibitors, which makes it highly effective against bacteria which are resistant, such as aminoglycosides, penicillins, cephalosporins, tetracyclines, and many others. Antibiotics. Ciprofloxacin acts as breeding microorganisms, and the rest are in phase. By ciprofloxacin susceptible gram-negative aerobic bacteria.

Sensitive to ciprofloxacin and gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae). Most staphylococci resistant to methicillin, and are resistant to ciprofloxacin.

The sensitivity of the bacteria Streptococcus pneumoniae, Enterococcus faecalis is moderate. For drug resistant Corynebacterium spp., Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. The drug against Treponema pallidum has been insufficiently studied. As in vitro, in vivo and is also sensitive to ciprofloxacin Bacillus anthracis.

Pharmacokinetics
Oral administration ciprofloxacin is quickly absorbed from the gastrointestinal tract. Ingestion delays absorption, but does not alter the bioavailability and maximum testosterone sustanon concentration. The bioavailability of the drug is 50-85%. The maximum drug concentration in the blood serum of healthy volunteers by oral intake (to food) 250, 500, 750 and 1000 mg of the drug attained 1-1.5 hours and is 1.2; 2.4; 4.3 and 5.4 ug / ml, respectively.

Oral ciprofloxacin received well distributed in tissues and body fluids. High drug concentrations are observed in the bile, lung, kidney, liver, gall bladder, uterus, seminal fluid, the prostate tissue, tonsils, endometrium, fallopian tubes and ovaries. The concentration of drug in these tissues than in the serum. Ciprofloxacin is also well into the bone, ocular fluid, bronchial secretions, saliva, skin, muscles, pleura, peritoneum, lymph. The cerebrospinal fluid penetrates in a small amount where its concentration in the non-inflamed meninges is 6-10% of that in the serum and in inflamed – 14-37%. Ciprofloxacin also penetrates well through the placenta. neutrophils in the blood concentration of ciprofloxacin in 2-7 times higher than in serum. The testosterone sustanon volume of distribution in the body is 2-3.5 l / kg. The degree of binding of ciprofloxacin to plasma proteins is 30%.

It is metabolized in the liver (15-30%) with the formation of inactive metabolites (dietiltsiprofloksatsin, sulfotsiprofloksatsin, oksotsiprofloksatsin, formiltsiprofloksatsin).