what is sustanon 250
With simultaneous application of ciprofloxacin and ciprofloxacin didanosine absorption is reduced due to the formation of complexes with ciprofloxacin contained in didanosine aluminum and magnesium salts.Due to the reduced activity of microsomal oxidation in hepatocytes concentration increases and extends the half-life of theophylline and / or caffeine (xanthines and others.) Peroralnyh what is sustanon 250 hypoglycemic drugs (glibenclamide – which can lead to hypoglycemia), anticoagulants, reduces prothrombin index.
Ciprofloxacin Cmax increases to 7 times tizanidine, which increases the risk of significant decrease of blood pressure and sleepiness.
Simultaneous treatment with non-steroidal anti-inflammatory drugs (except acetylsalicylic acid) – increases the risk of seizures.
Simultaneous administration of antacids, sucralfate, and preparations containing ions of aluminum, zinc, calcium, magnesium or iron, may cause a decrease in suction ciprofloxacin tsiprinol therefore be taken for what is sustanon 250hours before or after antacids 6 hours after ingestion.
In an application tsiprofoksatsina and cyclosporine nephrotoxicity is enhanced cyclosporine (requires monitoring of serum creatinine levels of 2 times per week).
Simultaneous administration of what is sustanon 250 and corticosteroids may increase the risk of tendon rupture.
Co-administration of ciprofloxacin and phenytoin may result in an increase or decrease in serum concentrations of phenytoin.
Metoclopramide accelerates the absorption of ciprofloxacin, which reduces the time to reach its maximum concentration in plasma.
Co-administration of uricosuric drugs leads to excretion slow down (to 50%) and increase in the plasma concentration of ciprofloxacin. When combined with other antimicrobial agents (beta-lactams, aminoglycosides, clindamycin, metronidazole) commonly observed synergism: the drug can be successfully applied in combination with ceftazidime and azlocillin in infections caused by Pseudomonas spp .;with mezlocillin, azlocillin and other beta-lactam antibiotics – in streptococcal infections; with izoksazolilpenitsillinami and vancomycin – with staphylococcal infections; metronidazole and clindamycin – In anaerobic infections.
Simultaneous use of probenecid and ciprofloxacin what is sustanon 250 reduces the renal clearance of ciprofloxacin, increasing its concentration in plasma. Simultaneous administration of ciprofloxacin and mexiletine can lead to increased concentrations of mexiletine.
In an application with piprofloksatsinom reduced tubular transport of methotrexate, which may potentially lead to an increase in its plasma concentrations. This increases the risk of toxicity of methotrexate.Patients receiving therapy with methotrexate, you must be under close medical supervision during treatment piprofloksatsinom.
In the event during or after the treatment with ciprofloxacin severe and prolonged diarrhea should exclude the diagnosis of pseudomembranous colitis, which requires immediate discontinuation of the drug and appropriate treatment.
In the event or pains in the tendons at the first signs tenosynovitis treatment should cease due to the fact that separate cases (mainly in elderly patients concomitantly receiving glucocorticoids) and inflammation of tendons even rupture during treatment fluoroquinolones. During therapy with ciprofloxacin are advised to avoid excessive physical exertion.
During treatment with ciprofloxacin, in order to avoid the development of crystalluria is unacceptable excess of the recommended daily dose. Also, you must acquire a sufficient amount of fluid (under the control of diuresis) to comply with normal urine output and maintain acidic urine.
The period of treatment should avoid ciprofloxacin what is sustanon 250 exposure (including exposure to direct sunlight). During therapy may increase the prothrombin index (during surgery should monitor the status of the blood coagulation system).
Patients with a deficiency of glucose-6-dehydrogenase ciprofloxacin assignment can cause the development of hemolytic anemia. During treatment, patients should not drink alcohol.
Effects on ability to management of motor transport and other mechanisms
Patients taking ciprofloxacin should be careful when driving and busy with other potentially hazardous activities that require increased attention and psychomotor speed reactions (especially with simultaneous use of alcohol).